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目的探讨慢性心力衰竭应用他汀类药物治疗的临床效果及安全性。方法将2012年11月至2014年11月收治的96例慢性心力衰竭患者作为研究对象,按随机数字表法分为两组。对照组48例采取常规方法治疗,观察组48例在常规方法治疗的基础上给予他汀类药物治疗,对比评估两组患者治疗前后心功能、左心室射血分数以及6 min步行距离指标变化情况。结果治疗前,两组心功能各级指标、左心射血分数以及6 min步行距离比较差异未见统计学意义(P>0.05);治疗后,观察组上述三项指标改善均显著优于对照组,差异有统计学意义(P<0.05)。结论对于慢性心力衰竭患者,采取他汀类药物治疗效果显著,能够使患者心功能得到有效改善,同时使患者运动功能得到有效强化,值得临床应用。
Objective To investigate the clinical effect and safety of statin therapy in patients with chronic heart failure. Methods 96 patients with chronic heart failure admitted from November 2012 to November 2014 were divided into two groups according to random number table. The control group of 48 patients treated by conventional methods, the observation group of 48 patients on the basis of conventional treatment of statins were given to compare the two groups of patients before and after treatment to assess cardiac function, left ventricular ejection fraction and 6-minute walking distance changes. Results Before treatment, the levels of cardiac function, left ventricular ejection fraction and walking distance at 6 min were not significantly different between the two groups (P> 0.05). After treatment, the above three indexes of the observation group were significantly better than the control Group, the difference was statistically significant (P <0.05). Conclusion For patients with chronic heart failure, taking statin therapy is significant, which can effectively improve the patient’s cardiac function, while allowing patients to effectively enhance the motor function, it is worth clinical application.