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目的:探讨放射治疗联合血管内皮抑制素对大鼠移植性肝癌的治疗作用。方法:SD大鼠随机分为5组:假手术组,模型组,血管内皮抑素组,放疗组,联合组,血管内皮抑素组和联合组每日尾静脉注射浓度为10%重组人血管内皮抑素0.1 ml(20μg),共12天,联合组在第5天～10天时给予放射治疗,1次/2天。各组动物于移植术后12d处死,分离肿瘤组织备用。结果:血管内皮抑素组、放疗组、联合组均能显著抑制肿瘤生长,抑制VEGF表达,其中联合组抑制效果更为明显。结论:放射治疗联合血管内皮抑制素有明显肿瘤抑制作用,其机制可能与下调VEGF的表达有关。
Objective: To investigate the therapeutic effect of radiotherapy combined with endostatin on transplanted liver cancer in rats. Methods: SD rats were randomly divided into 5 groups: sham operation group, model group, endostatin group, radiotherapy group, combination group, endostatin group and the combination group daily tail vein injection concentration of 10% recombinant human blood vessels Endostatin 0.1 ml (20μg) for 12 days, the combination group on the 5th to 10 days to give radiation therapy, 1 time / 2 days. Animals in each group were sacrificed 12 days after transplantation, and the tumor tissue was separated for use. Results: Endostatin group, radiotherapy group and combination group all could significantly inhibit the growth of tumor and inhibit the expression of VEGF. The inhibitory effect was more obvious in combination group. Conclusion: Radiotherapy combined with endostatin has obvious tumor inhibitory effect, the mechanism may be related to the down-regulation of VEGF expression.