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目的探讨血清 C-反应蛋白(CRP)、TNF-α及IL-6与2型糖尿病肾病的关系。方法根据尿白蛋白排泄率(UAER)选取64例2型糖尿病患者,其中糖尿病肾病40例,分别为蛋白尿组1(DN1)18例和临床蛋白尿组2(DN2)22例,其余为正常蛋白尿组(DM)24例。另选40例作为正常对照组。观察各组血清 CRP、TNF-α及 IL-6水平。血清 CRP 水平采用 ELASA 法测定,TNF-α及 IL-6水平采用电化学发光法测定。结果 DN1组及DN2组血清 CRP、TNF-α及 IL-6水平较正常对照组升高,与 DM组比较也升高,而 DN2组升高的更明显。DN1组及DN2组血清 CRP 与 TNF-α及 IL-6呈正相关。结论血清 CRP、TNF-α及 IL-6水平与糖尿病肾病的程度呈一致性。
Objective To investigate the relationship between serum C-reactive protein (CRP), TNF-α and IL-6 and type 2 diabetic nephropathy. Methods According to the urinary albumin excretion rate (UAER), 64 patients with type 2 diabetes mellitus were selected. Among them, 40 patients with diabetic nephropathy were DN1 (DN1) 18 and DN2 (DN2) 22 and the rest were normal Proteinuria group (DM) in 24 cases. Another 40 cases as a normal control group. The levels of serum CRP, TNF-α and IL-6 in each group were observed. Serum CRP levels were measured by ELASA method, and the levels of TNF-α and IL-6 were measured by electrochemiluminescence. Results Serum levels of CRP, TNF-α and IL-6 in DN1 group and DN2 group were higher than those in normal control group, but also increased in DM group and DN2 group. Serum levels of CRP in DN1 and DN2 groups were positively correlated with TNF-α and IL-6. Conclusion Serum levels of CRP, TNF-α and IL-6 are consistent with those of diabetic nephropathy.