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目的:探讨抗精子抗体(ASAB)、抗子宫内膜抗体(EMAB)与习惯性流产的关系。方法:用酶联免疫吸附试验(ELISA)检测受检者血清ASAB和EMAB,并分析其与习惯性流产的关系。结果:习惯性流产组的ASAB和EMAB阳性率分别为6.4%和33.0%,均明显高于对照组的3.4%和13.8%(P<0.01);早期流产(孕龄<12周)患者的ASAB和EMAB阳性率分别为9.8%和44.3%,明显高于晚期流产(孕龄≥12周)患者的0和12.1%(P<0.01);初次流产年龄<20岁患者两项免疫学指标(ASAB阳性或EMAB阳性)的总阳性率为64.9%,明显高于初次流产年龄≥20岁患者的35.1%(P<0.01)。结论:ASAB和EMAB与子宫内膜发生抗原抗体反应,干扰受精卵的着床和发育,导致反复流产,尤其是早期流产。
Objective: To investigate the relationship between anti-sperm antibody (ASAB), anti-endometrial antibody (EMAB) and habitual abortion. Methods: Serum ASAB and EMAB were detected by enzyme-linked immunosorbent assay (ELISA), and their relationship with habitual abortion was analyzed. Results: The positive rates of ASAB and EMAB in habitual abortion group were 6.4% and 33.0%, respectively, which were significantly higher than those in control group (3.4% vs 13.8%, P <0.01) And EMAB were 9.8% and 44.3%, respectively, which were significantly higher than those in patients with advanced miscarriage (gestational age ≥12 weeks) (P <0.01). The two immunological indexes (ASAB Positive or positive for EMAB) was 64.9%, which was significantly higher than 35.1% (P <0.01) of the patients of the first miscarriage ≥20 years old. CONCLUSIONS: ASAB and EMAB react with antigen and antibody in endometrium and interfere with implantation and development of fertilized eggs, leading to recurrent abortion, especially early abortion.