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目的研究乙型肝炎(乙肝)疫苗免疫时代人群乙肝病毒(HBV)感染状况与抗体水平。方法于1984年、1999年分别采集上海市黄浦区(原南市区)1~49岁人群血清1540份和838份,检测乙肝病毒表面抗原(HBsAg)、乙肝病毒表面抗体(抗-HBs)、乙肝病毒核心抗体(抗-HBc),分析并比较各组HBV携带率与感染率。结果1999年横断面调查中,各年龄组HBV携带率与感染率较1984年各年龄组均有所下降,其中以免疫人群下降更为显著。结论新生儿乙肝疫苗免疫是控制及消除人群HBV感染的有效措施。
Objective To study the status of hepatitis B virus (HBV) infection and antibody level in the age of hepatitis B (HBV) immunization. Methods A total of 1540 and 838 serum samples from 1 to 49 years old were collected from Huangpu District of Huangpu District of Shanghai in 1984 and 1999 respectively. The HBsAg, HBsAg, Hepatitis B virus core antibody (anti-HBc), analysis and comparison of HBV carrier rate and infection rate in each group. Results In the cross-sectional survey in 1999, the HBV carrier rate and infection rate of all age groups were all lower than those of all age groups in 1984, of which the immunization population declined more significantly. Conclusion Neonatal hepatitis B vaccine immunization is an effective measure to control and eliminate HBV infection in the population.