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通过胰岛素、C肽释放试验,观察了硝苯吡啶、硫氮酮和异搏定对胰岛β细胞功能的影响。结果显示,治疗剂量的硝苯吡啶和硫氮酮具有抑制胰岛β细胞分泌的作用,为糖尿病病人应用此类药物提供理论基础。
The effects of nifedipine, diltiazem and verapamil on pancreatic β-cell function were observed by insulin and C-peptide release assay. The results showed that the therapeutic doses of nifedipine and diltiazem have the effect of inhibiting the secretion of pancreatic β-cells, and provide the theoretical basis for the application of such drugs in diabetic patients.