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FMS样酪氨酸激酶3(FLT3),是Ⅲ型酪氨酸激酶受体(RTKⅢ)的一种,优先表达在定向造血干细胞的细胞表面,与FLT3配体(FL)的相互作用在造血过程的维持,增殖和分化中发挥重要作用。FLT3基因的活性突变是急性髓系白血病(AML)最常见的基因损伤,而且FLT3基因突变通常会给AML患者带来更差
FMS-like tyrosine kinase 3 (FLT3), a type III tyrosine kinase receptor (RTKIII), is preferentially expressed on the cell surface of targeted hematopoietic stem cells and interacts with FLT3 ligand (FL) during hematopoietic Play an important role in the maintenance, proliferation and differentiation. The active mutation of the FLT3 gene is the most common gene injury in acute myeloid leukemia (AML), and mutations in the FLT3 gene usually result in poorer AML patients