Squamous cell carcinoma (SCC) is the most common in oral and maxillofacial regions and occupy more than 90％ of the malignant lesions in the oral cavity[1]. The complex anatomy of the head and neck region gives rise to intricate patterns of local invasion and regional spread, which makes primary tumors more difficult to eradicate. Surgical resection combined with chemotherapy using cytotoxic drugs or radiation therapy are routine means for the treatment of SCC. However, drug resistance, severe side effects, and high recurrence rate markedly limit the effectiveness of clinical treatments. Consequently, the search for novel anti-cancer strategies with low toxicity has acquired the interest of many researchers.