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目的:探讨Survivin蛋白在喉鳞状细胞癌和成人喉乳头状瘤中的表达及其意义。方法:应用免疫组化方法对46例喉鳞状细胞癌、24例癌旁组织和20例喉乳头状瘤以及16例正常喉粘膜标本中Survivin的表达进行检测。结果:Survivin蛋白在喉癌组织、癌旁组织和喉乳头状瘤中的阳性表达率分别为71.74%(33/46)、33.33%(8/24)和40.0%(8/20),在正常黏膜组织中没有表达,喉癌组中的阳性表达率分别显著高于正常组织、癌旁组织及喉乳头状瘤中的表达率(均P<0.01)。且发生恶变的喉乳头状瘤Survivin蛋白均为阳性表达。但Sur-vivin阳性表达与喉癌的发生部位、分级、分期、淋巴结转移以及病理分级没有关联。结论:Survivin在喉癌组织中过度表达,参与了喉癌的形成,是喉癌形成的一个早期事件,可望成为预测成人喉乳头状瘤恶变的一个诊断方法。
Objective: To investigate the expression and significance of Survivin protein in laryngeal squamous cell carcinoma and laryngeal papilloma. Methods: The expression of Survivin in 46 cases of laryngeal squamous cell carcinoma, 24 cases of paracancerous tissues, 20 cases of laryngeal papilloma and 16 cases of normal laryngeal mucosa were detected by immunohistochemistry. Results: The positive rates of Survivin protein expression in laryngeal carcinoma tissues, para-carcinoma tissues and laryngeal papillomas were 71.74% (33/46), 33.33% (8/24) and 40.0% (8/20), respectively. There was no expression in mucosal tissues. The positive expression rate in laryngeal carcinoma was significantly higher than that in normal tissues, adjacent tissues and laryngeal papilloma (all P <0.01). Survivin protein was positive in malignant laryngeal papilloma. However, the positive expression of Sur-vivin was not associated with the location, grade, stage, lymph node metastasis and pathological grade of laryngeal carcinoma. Conclusion: Survivin is overexpressed in laryngeal squamous cell carcinoma and is involved in the formation of laryngeal carcinoma. It is an early event in the formation of laryngeal carcinoma and may be a diagnostic method for predicting the malignancy of adult laryngeal papilloma.