一、概述类风湿性关节炎(rheumatoid arthritis,RA)是一种慢性自身免疫性炎性疾病,以滑膜增生、关节破坏及关节外表现为特征。虽然病因尚不明确,但已知滑膜中性粒细胞、滑膜巨噬细胞、滑膜成纤维细胞、T细胞和B细胞均涉及RA的发病,T、B细胞及巨噬细胞浸润滑膜,形成不连续的淋巴样聚集,甚至有时滑膜中 I. Overview Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by synovial hyperplasia, joint destruction and extra-articular manifestations. Although the cause is not clear, it is known that synovial neutrophils, synovial macrophages, synovial fibroblasts, T cells and B cells are all involved in the pathogenesis of RA. T, B cells and macrophages are infiltrating the synovial membrane , Forming a discontinuous lymphoid aggregation, sometimes even in the synovium