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根据人体胃肠环境变化特点,调节4个明矾炮制药材的水煎液的酸度,于37℃恒温水浴中保持1h之后,用0.45μm微孔滤膜、732氢型阳离子交换树脂分离水煎液中各种铝形态。湿法消解-石墨炉原子吸收光谱法(GFAAS)测定总铝量;GFAAS直接测定水煎液中各形态铝含量。得到了各样品中铝形态含量及分布情况,并且与未调节酸度的样品进行比较,讨论铝在胃肠的模拟系统影响下的形态转变原因。所得结果对明矾炮制药材中铝的安全性评价有参考价值。
According to the characteristics of human gastrointestinal changes, adjust the acidity of decoction of four alum medicinal herbs, keep in water bath at 37 ℃ for 1h, then use 0.45μm microporous membrane, 732 hydrogen cation exchange resin to separate the decoction Various forms of aluminum. Wet digestion - graphite furnace atomic absorption spectrometry (GFAAS) Determination of total aluminum; GFAAS direct determination of various forms of decoction aluminum content. The content and distribution of aluminum species in each sample were obtained and compared with the samples without acidity adjustment to discuss the reasons for the morphological changes of aluminum under the influence of gastrointestinal system. The obtained results have reference value for the safety evaluation of aluminum in alum processed medicinal materials.