白细胞介素8是属于趋化因子超家族CXC亚家族的一个成员。近年研究显示,包括头颈部鳞癌在内的大多数恶性肿瘤都有IL-8阳性表达,推测其可能作为一种重要的促血管再生因素参与肿瘤进程。深入研究IL-8与头颈部鳞癌的关系,不仅对了解头颈部鳞癌的致病机制具有重要意义,针对IL-8和肿瘤微血管生成而控制肿瘤生长和转移的治疗策略,也具有广阔的临床应用前景。 Interleukin 8 is a member of the CXC subfamily of chemokine superfamilies. Recent studies have shown that most malignant tumors, including head and neck squamous cell carcinoma, have positive expression of IL-8, suggesting that they may play an important role as proangiogenesis factors in tumor progression. In-depth study of IL-8 and head and neck squamous cell carcinoma, not only for understanding the pathogenesis of head and neck squamous cell carcinoma is of great significance, for IL-8 and tumor angiogenesis and control of tumor growth and metastasis of the treatment strategy also has Broad clinical application prospects.