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目前认为血管内皮细胞损伤是血栓性血小板减少性紫癜(TTP)的致病因素之一。为观察TTP 患者血循环中的血栓调理素浓度的变化,作者测定了13例(男4例,女9例,年龄18～79岁)急性TTP 患者血循环中的血栓调理素浓度。这些患者有血小板减少、有破碎红细胞的溶血性贫血、多变的神经系体征,轻度肾功能不全或出血等TTP 的主要临床表现。乳酸脱氢酶(LDH)、肌酐高于正常。4例合并系统性红斑狼疮(SLE)。13例中9例获缓解,另4例死亡。还同时测定了34名健康人作对照。对照组活化的部分凝血活酶时间(APTT)25.4～36.3秒,凝血酶原时间(PT)10.7～13.5秒,纤维蛋白原2.0～3.5g/L,纤维蛋白原降解产物(FDP)<2μg/ml,组织型纤维蛋白
Now that vascular endothelial cell damage is thrombotic thrombocytopenic purpura (TTP) one of the risk factors. To investigate the changes in blood thrombomodulin concentrations in patients with TTP, the authors measured the thrombomodulin concentrations in the bloodstream of 13 acute TTP patients (4 males and 9 females, aged 18-79 years). These patients have the main clinical manifestations of TTP, such as thrombocytopenia, hemolytic anemia with broken red blood cells, changing neurological signs, mild renal insufficiency or bleeding. Lactate dehydrogenase (LDH), creatinine higher than normal. 4 patients with systemic lupus erythematosus (SLE). Nine of 13 patients were relieved and the other four died. Also measured 34 healthy people as a control. The activated partial thromboplastin time (APTT) 25.4-36.3 seconds, prothrombin time 10.7-13.5 seconds, fibrinogen 2.0-3.5 g / L, fibrinogen degradation product FDP 2μg / ml, tissue fibrin