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目的探究奥硝唑与甲硝唑治疗滴虫性阴道炎的临床疗效和不良反应发生情况。方法 80例滴虫性阴道炎患者,随机分为对照组与观察组,每组40例。对照组患者采用甲硝唑进行治疗,观察组患者则采用奥硝唑进行治疗。比较两组患者的治疗效果、不良反应发生情况,以及白介素-13(IL-13)、白介素-8(IL-8)、白介素-2(IL-2)水平变化情况。结果治疗后,观察组患者的总有效率95.00%显著高于对照组的80.00%,差异具有统计学意义(P<0.05)。观察组患者的不良反应发生率20.00%明显低于对照组的5.00%,差异具有统计学意义(χ~2=4.114,P<0.05)。治疗后,对照组IL-13水平为(25.51±1.20)pg/ml、IL-8水平为(2.92±0.50)pg/ml;观察组IL-13水平为(22.12±0.51)pg/ml、IL-8水平为(1.51±0.24)pg/ml;观察组的IL-13、IL-8水平明显高于对照组,差异具有统计学意义(P<0.05)。两组患者的IL-2水平比较差异无统计学意义(P>0.05)。结论对滴虫性阴道炎应用奥硝唑进行治疗,其治疗效果显著,值得临床进一步推广与应用。
Objective To investigate the clinical efficacy and adverse reactions of ornidazole and metronidazole in the treatment of trichomonas vaginitis. Methods Eighty patients with trichomonal vaginitis were randomly divided into control group and observation group, 40 cases in each group. Patients in the control group were treated with metronidazole, while patients in the observation group were treated with ornidazole. The therapeutic effects, adverse reactions and the changes of IL-13, IL-8 and IL-2 in the two groups were compared. Results After treatment, the total effective rate in the observation group was 95.00%, significantly higher than that in the control group (80.00%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (20.00% vs 5.00%, χ ~ 2 = 4.114, P <0.05). After treatment, the level of IL-13 in the control group was (25.51 ± 1.20) pg / ml and the level of IL-8 was (2.92 ± 0.50) pg / ml; -8 and (1.51 ± 0.24) pg / ml respectively. The level of IL-13 and IL-8 in the observation group was significantly higher than that in the control group, with statistical significance (P <0.05). There was no significant difference in IL-2 levels between the two groups (P> 0.05). Conclusion The treatment of trichomonas vaginitis with ornidazole, the treatment of significant effect, it is worth further clinical application and application.