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以 40 %四氯化碳花生油诱导大鼠肝纤维化模型 ,同时用重组干扰素 α2 b( IFN-α2 b)及秋水仙碱 ( COL )做预防性治疗 ,观察 IFN-α2 b对大鼠肝纤维化形成的影响。结果发现 IFN- α2 b及 COL治疗组血清 AL T、AST、 型前胶原、 型胶原及透明质酸水平 ,以及肝组织纤维化程度均显著低于模型组 ,IFN- α2 b组肝组织炎症活动度及 、 型胶原 ,TNF- α显色指数均显著小于模型组。作者认为 ,IFN- α2 b可通过保护肝细胞、减轻肝组织炎症坏死、抑制 TNF- α对贮脂细胞的激活等机制 ,而抑制大鼠肝纤维化的形成
The model of hepatic fibrosis was induced by 40% carbon tetrachloride peanut oil. At the same time, IFN-α2b and colchicine were used as prophylactic treatment to observe the effects of IFN-α2b on rat liver Effect of fibrosis formation. The results showed that serum levels of ALT, AST, procollagen, collagen, hyaluronic acid and liver fibrosis in IFN-α2b and COL treatment group were significantly lower than those in model group and IFN-α2b group Degree and type collagen, TNF-α color index were significantly less than the model group. The authors believe that IFN-α2b can inhibit the formation of hepatic fibrosis in rats by protecting liver cells, reducing inflammation and necrosis of liver tissue and inhibiting the activation of fat-storing cells by TNF-α