采用流式细胞术连续监测 8只幼年猴自出生后 1月～ 5月天然抗体的演变 ,并检测 9只成年猴天然抗体IgM水平。幼年猴 1月龄前天然抗体IgM阳性细胞比例较低 (9 9%± 6 3% ) ,到 3月龄时可达成年猴的 4 0 % ,5月龄时接近成年水平。 9只成年猴天然抗体IgM阳性细胞比例变化幅度很大 ,从 94 9%到 2 6 3% (均数 77 3%± 2 1 5 % )。提示 3月龄前幼年猴可用作避免超急性排斥反应的受体模型。不管是成年猴还是幼年猴 ,被选择为实验受体进行移植研究时 ,应事先对其体内的天然抗体水平进行检测 ,以确保实验的可比性。 Flow cytometry was used to monitor the evolution of natural antibodies in 8 juvenile monkeys from January to May after birth. The IgM levels of 9 natural monkeys were detected. The percentage of IgM positive cells in young monkeys before 1 month of age was lower (9 9% ± 6 3%), reached 40% in 3-month-old chickens and approached to adult level at 5 months of age. The proportions of IgM positive cells in nine adult monkeys varied widely, from 94 9% to 263% (mean 77 3% ± 21 5%). It suggests that juvenile monkeys aged 3 months old can be used as a model to avoid hyperacute rejection. Regardless of adult monkey or young monkey, was selected as the experimental recipient for transplant study, the level of natural antibodies in vivo should be tested in advance to ensure the comparability of the experiment.