Objective To explore the effects and underlying mechanisms of high glucose on in vitro invasiveness of human breast cancer cell line MDA-MB-435. Methods The invasiveness of MDA-MB-435 was determined by Matrigel-coated transwell chambers. Reverse Objective To explore the effects and underlying mechanisms of high glucose on in vitro invasiveness of human breast cancer cell line MDA-MB-435. Methods The invasiveness of MDA-MB-435 was determined by Matrigel-coated transwell chambers. Reverse