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目的观察苍耳子致肝损伤是否具有可逆性及对肝组织DNA合成的影响。方法连续4周灌胃小鼠苍耳子水煎液,停药2周后观察其对体重及肝脏功能的影响;并用3H-胸腺嘧啶核苷(3H-TdR)示踪法研究血清中和组织中的放射性活度。结果苍耳子对小鼠体重的增长有一定的抑制作用,但此作用可在停药后自行消失;血液生化指标在停药2周后,苍耳子中、高剂量组谷草转氨酶(AST)仍显著高于空白组;苍耳子低、中剂量时肝组织的DNA受到损伤,在高剂量时DNA合成受到影响。结论苍耳子肝损伤在一定剂量范围内具有可逆性;苍耳子对肝组织DNA合成有一定影响。
Objective To observe whether the Xanthium sibiricum liver injury is reversible and its effect on DNA synthesis in liver tissue. Methods The mice were decocted with Xanthium decoction for 4 weeks, and the effects on body weight and liver function were observed after 2 weeks of discontinuation. Serum 3H-TdR was used to study the serum-neutralizing tissues. The activity in the radioactivity. Results Xanthium sibiricum had a certain inhibitory effect on the weight gain of mice, but this effect disappeared after discontinuation; blood biochemical indicators after 2 weeks of discontinuation, middle and high doses of Xanthium sinensis AST Still significantly higher than the blank group; Xanthium low and medium doses of liver DNA damage, DNA synthesis at high doses affected. Conclusion Xanthium hepatic injury is reversible within a certain dose range; Xanthium has some influence on DNA synthesis in liver tissue.