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目的观察注射用蛇毒血凝酶治疗支气管镜检肺组织中出血的临床疗效。方法选取我科2008年5月～2011年5月行电子支气管镜检查的患者64例,随机分为治疗组与对照组,两组患者在检查过程中均有因活检出血或其他出血情况,治疗组在发现出血后血凝酶局部给药,给药量1kU,用生理盐水稀释后给药;对照组使用肾上腺素稀释后局部给药,最大剂量不超过1mg,对比两种方法的止血时间、再出血率、镜检后痰血率以及血压升高、局部黏膜改变等副作用。结果治疗组与对照组比较,止血时间、再出血率、镜检后痰血率差异无统计学意义(P>0.05),而治疗组副作用较对照组少,更加安全。结论血凝酶对支气管镜检中肺组织出血有良好的止血效果,且副作用轻微,适合在临床推广使用。
Objective To observe the clinical efficacy of intravenous injection of hemagglutinin for bronchial hemorrhage in bronchoscopy. Methods Sixty-four patients undergoing electronic bronchoscopy from May 2008 to May 2011 in our department were randomly divided into treatment group and control group. Both groups were treated by biopsy or other bleeding during the examination Group after hemorrhage found local administration of hemagglutinin, the dose of 1kU, diluted with saline administered; control group with epinephrine diluted local administration, the maximum dose of not more than 1mg, compared to the two methods of bleeding time, The rate of rebleeding, the rate of sputum after microscopy and blood pressure, local mucosal changes and other side effects. Results Compared with the control group, there was no significant difference between the treatment group and the control group in the bleeding time, the rate of rebleeding and the sputum blood rate after the microscopic examination (P> 0.05). The side effects in the treatment group were less and more secure than those in the control group. Conclusions Hemagglutinin has a good hemostatic effect on bronchial hemorrhage in lung tissues during bronchoscopy with mild side effects and is suitable for clinical use.