在放射治疗实践过程中发现,放射敏感性在个体间存在差别,一些特定个体不能忍受放射治疗的“常规”剂量。应用集落存活分析法(CSA)研究表明,共济失调性毛细血管扩张症病人的ATM基因突变导致个体放射敏感性增强,同时许多其他种类遗传性紊乱的相关基因也被明确定位,这些基因突变导致放射敏感性增强的机制正逐渐被阐明。应用CSA方法可以得到一个能决定人类放射敏感性的基因谱,并可以此作为对特殊放射敏感性病人的治疗指导。 In the practice of radiation therapy found that radiosensitivity differences exist among individuals, some individuals can not tolerate the “conventional” dose of radiation therapy. Studies using colony-forming assay (CSA) indicate that mutations in ATM genes in patients with ataxia telangiectasia lead to increased radiosensitivity in individuals, and that genes associated with many other genetic disorders are also specifically targeted and mutations in these genes result in The mechanism of increased radiosensitivity is gradually being elucidated. Using the CSA method, a gene profile that determines human radiosensitivity can be obtained and used as a guideline for the treatment of patients with specific radiosensitivities.