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目的探讨亚低温联合依达拉奉治疗大面积脑梗死的临床疗效。方法将36例大面积脑梗死患者,随机分为亚低温和依达拉奉治疗组18例,对照组18例,于治疗前及治疗后14d对患者神经功能缺损程度及临床效果进行评定。结果治疗后治疗组神经功能缺损评分明显低于对照组,临床疗效优于对照组,两组比较差异有统计学意义(P<0.05)。结论亚低温联合依达拉奉治疗大面积脑梗死疗效显著,不良反应少,可在临床广泛应用。
Objective To investigate the clinical effect of mild hypothermia combined with edaravone in treating large area cerebral infarction. Methods Thirty-six patients with large area cerebral infarction were randomly divided into mild hypothermia and edaravone treatment group (18 cases) and control group (18 cases). The degree of neurological deficit and clinical effect were evaluated before treatment and 14 days after treatment. Results After treatment, the score of neurological deficit in the treatment group was significantly lower than that of the control group, and the clinical efficacy was better than that of the control group. There was significant difference between the two groups (P <0.05). Conclusions Mild hypothermia combined with edaravone has significant curative effect on large area cerebral infarction with few adverse reactions and can be widely used in clinical practice.