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目的探讨血液灌流联合血液透析治疗尿毒症疗效及对患者肾功能的影响。方法 62例尿毒症患者随机分为对照组和观察组,各31例。对照组给予血液透析治疗,观察组给予血液灌流联合血液透析治疗。比较两组患者血液毒性物质清除情况和肾功能的变化。结果治疗后,观察组患者尿素氮(BUN)、血清钙离子(Ca~(2+))、甲状旁腺激素(PTH)的水平分别为(10.1±3.5)mmol/L、(1.76±0.31)mmol/L、(167.3±72.1)ng/L低于对照组(16.3±3.8)mmol/L、(2.09±0.31)mmol/L、(239.5±77.8)ng/L;观察组残存肾功能为(1.23±0.52)ml/min优于对照组(0.61±0.21)ml/min,差异均具有统计学意义(P<0.05)。结论血液灌流联合血液透析治疗尿毒症可有效清除血液中有毒物质,另外可有效改善患者残存肾功能,改善患者临床症状,值得在临床中推广应用。
Objective To investigate the therapeutic effect of hemoperfusion and hemodialysis on uremia and its effect on renal function in patients. Methods 62 patients with uremia were randomly divided into control group and observation group, 31 cases in each. The control group was given hemodialysis treatment, and the observation group was given hemoperfusion combined with hemodialysis treatment. The clearance of hematological toxicants and changes of renal function were compared between the two groups. Results After treatment, the levels of BUN, Ca2 + and PTH in the observation group were (10.1 ± 3.5) mmol / L and (1.76 ± 0.31) (167.3 ± 72.1) ng / L was lower than that of the control group (16.3 ± 3.8 mmol / L, 2.09 ± 0.31 mmol / L and (239.5 ± 77.8) ng / L, 1.23 ± 0.52) ml / min better than the control group (0.61 ± 0.21) ml / min, the difference was statistically significant (P <0.05). Conclusion Hemoperfusion combined with hemodialysis can effectively remove the toxic substances in the blood, and can effectively improve the residual renal function and improve the clinical symptoms of patients, which is worth popularizing in clinic.