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采用分子印迹技术,分别采用反相乳液聚合方法和反相悬浮聚合法,以阿司匹林为目标印迹分子,分别以丙烯酰胺、β-环糊精(β-CD)为功能单体,合成了阿司匹林分子印迹聚合物微球。2种聚合物微球的红外光谱红移表明丙烯酰胺与Asp之间作用以氢键为主,而β-CD与Asp之间形成氢键和包结并存的两种作用方式。吸附研究表明两种分子印迹微球对Asp保留了印迹效应,且两种分子印迹微球均存在两种不同亲和力的结合位点。但P(βAsp)对Asp的结合性能与P(AAsp)相比更强。
The molecular imprinting technique was used to synthesize aspirin molecules by reverse phase emulsion polymerization and reverse phase suspension polymerization respectively with aspirin as the target imprinted molecule and acrylamide and β-cyclodextrin (β-CD) Imprinted polymer microspheres. The red shift of the IR spectra of the two kinds of polymer microspheres indicates that the main interaction between acrylamide and Asp is hydrogen bonding, and the two modes of action of hydrogen bonding and inclusion coexistence of β-CD and Asp exist. Adsorption studies showed that both molecularly imprinted microspheres retained the imprinting effect on Asp, and both molecularly imprinted microspheres had two different affinity binding sites. However, the binding of P (Asp) to Asp was stronger than that of P (AAsp).