论文部分内容阅读
目的:观察左归丸加减联合安宫黄体酮治疗卵巢早衰的临床疗效。方法:将120例卵巢早衰患者根据就诊时间顺序随机分为治疗组、西药组、中药组,每组40例。治疗组予以左归丸加减联合安宫黄体酮治疗,西药组予雌激素联合安宫黄体酮治疗,中药组单予左归丸加减治疗,3组均以1个月为1疗程,连续治疗3个疗程。比较3组治疗前后血清性激素、左右卵巢体积及子宫内膜厚度的变化,并比较3组临床疗效。结果:总有效率治疗组为85.0%,西药组和中药组分别为67.5%、72.5%,治疗组优于西药组和中药组(P<0.05);治疗组对血清性激素中E2、FSH、LH水平及子宫内膜厚度的改善均优于中药组和西药组,差异有统计学意义(P<0.05);3组在卵巢体积的改善方面差异无统计学意义(P>0.05)。结论:左归丸加减联合安宫黄体酮治疗卵巢早衰具有较为肯定的疗效,与单纯西药治疗及单纯中药治疗相比具有较优的疗效及安全性,且无明显毒副作用,值得进一步临床应用和深入研究。
Objective: To observe the clinical curative effect of Zuogui Pill combined with An Gong progesterone in the treatment of premature ovarian failure. Methods: 120 cases of premature ovarian failure were randomly divided into treatment group, western medicine group and traditional Chinese medicine group according to the order of treatment, 40 cases in each group. The patients in the treatment group were treated with Zuogui Pill and the combination of the medroxyprogesterone acetate. The western medicine group was treated with estrogen combined with the medroxyprogesterone acetate. The Chinese medicine group was treated with Zuogui Pill only. The treatment groups were given 1 course of treatment for 1 month, Treatment of 3 courses. The changes of serum sex hormones, ovarian volume and endometrial thickness before and after treatment were compared between the three groups. The clinical efficacy was compared between the three groups. Results: The total effective rate was 85.0% in the treatment group, 67.5% in the western medicine group and 72.5% in the traditional Chinese medicine group. The treatment group was superior to the Western medicine group and the traditional Chinese medicine group (P <0.05) (P <0.05). There was no significant difference in ovarian volume between the three groups (P> 0.05) .Conclusion: The improvement of ovarian volume and endometrial thickness are better than traditional Chinese medicine group and western medicine group. Conclusion: The combination of Zuogui Pill and An Decoction of progesterone progesterone in the treatment of premature ovarian failure has a certain effect, with simple Western medicine and simple Chinese medicine treatment has better efficacy and safety, and no significant side effects, it is worth further clinical application And in-depth study.