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前列腺癌(PCa)是一种最常见的恶性肿瘤,据2010年美国癌症协会估计每年新发病例在各种肿瘤中最多,死亡率仅次于肺癌。未发生远处转移的PCa患者的5年生存率已接近100%,但是,发生转移的PCa患者的预后很差。因此研究肿瘤转移的机制尤其是肿瘤细胞如何从原位脱离就显得非常重要。在本文中,我们将讨论目前最流行的转移机制上皮间质转化的作用及其在PCa转移中的潜在作用。我们也将进一步讨论了间质上皮转化及其在肿瘤转移中的作用,最后是两者的相互作用在肿瘤转移全过程中的作用。
Prostate cancer (PCa) is one of the most common malignant tumors. According to the 2010 American Cancer Society, annual new cases are estimated to be the most frequently occurring in all kinds of tumors with the second highest mortality rate after lung cancer. The 5-year survival rate of PCa patients without distant metastases is close to 100%, however, the prognosis of PCa patients with metastases is poor. Therefore, it is very important to study the mechanism of tumor metastasis, especially how the tumor cells are detached from the tumor. In this article, we will discuss the role of the most popular metastatic mechanism of epithelial-mesenchymal transition and its potential role in PCa metastasis. We will further discuss the role of stromal epithelial transformation and its role in tumor metastasis, and finally the interaction between the two in the entire process of tumor metastasis.