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目的观察戊乙奎醚在重症有机磷中毒(OPP)伴中枢神经系统(CNS)损害的治疗作用。方法回顾性分析66例重症OPP伴CNS损害患者资料,其中,31例以戊乙奎醚治疗(P组),35例采用传统阿托品治疗(C组),比较两组患者CNS中毒症状持续时间、胆碱酯酶活力(ChE)恢复情况、不良反应发生率及治愈率。结果与C组比较,P组CNS症状持续时间明显缩短[(9.28±3.69)hvs.(21.35±11.68)h](P<0.01),毒蕈碱样症状持续时间也明显缩短[(0.58±0.45)hvs.(4.05±3.68)h](P<0.01),中毒后72h的ChE活力明显升高[(72.67±35.04)%vs.(40.17±23.43)%](P<0.01),不良反应发生率低,治愈率高(P<0.01)。结论戊乙奎醚治疗重症有机磷中毒伴中枢神经系统损害者较阿托品疗效好,不良反应发生率低。
Objective To observe the therapeutic effect of penehyclidine on central nervous system (CNS) damage caused by severe organophosphorus poisoning (OPP). Methods The data of 66 patients with severe OPP complicated with CNS were retrospectively analyzed. Among them, 31 patients were treated with pemetrexed (P group) and 35 patients were treated with traditional atropine (C group). The duration of CNS poisoning was compared between the two groups. Cholinesterase activity (ChE) recovery, the incidence of adverse reactions and cure rates. Results The duration of CNS symptoms was significantly shorter in group P than in group C [(9.28 ± 3.69) hvs. (21.35 ± 11.68) h] (P <0.01), and the duration of muscarinic symptoms was also significantly shorter than that in group C [(0.58 ± 0.45 (P <0.01). The activity of ChE was significantly increased at 72h after poisoning (72.67 ± 35.04 vs 40.17 ± 23.43)% (P <0.01), and the adverse reaction occurred Low rate, high cure rate (P <0.01). Conclusion Penehyclidine treatment of severe organophosphate poisoning with central nervous system damage than atropine good effect, the incidence of adverse reactions is low.