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目的通过血液流变学研究组织黏合剂 N-丁基-2-氰丙烯酸盐在模拟血管中的实际行为,分析影响其闭合血管的主要因素,找到发挥作用的最佳条件。方法利用聚四氟乙烯管建立血流模拟装置,分别研究血管直径、血流速度以及组织黏合剂配比浓度这三个因素对组织黏合剂闭合血管的影响。结果组织黏合剂与碘油1:1配比混合物1.0 ml 快速注射至聚四氟乙烯管内可以完全阻塞血流速度15 cm/s、直径0.4 cm 的以及血流速度10 cm/s 且直径0.6 cm 的血流。当管腔直径增加至0.8 cm 或血流速度加快为20 cm/s 时,血流只是部分闭塞。改变组织黏合剂与碘油配比为0.5:0.8以及0.5:1.0,则注射后聚合体断裂成碎片状。结论实验验证了随着血管直径增大、血流速度加快及配比浓度降低,组织黏合剂闭合血管的效应下降,以供临床定量参考。
Objective To study the actual behavior of tissue adhesive N-butyl-2-cyanoacrylate in mimicking blood vessels by hemorheology and to analyze the main factors influencing occlusion of blood vessels and to find out the optimal conditions for its action. Methods Teflon tube was used to establish a blood flow simulation device to study the effects of vascular diameter, blood flow velocity and the proportion of tissue adhesive on vascular occlusion of tissue adhesives. Results The rapid injection of 1.0 ml of a 1: 1 mixture of tissue adhesive and lipiodol into the Teflon tube completely obstructed the blood flow rate of 15 cm / s, the diameter of 0.4 cm and the blood flow velocity of 10 cm / s and the diameter of 0.6 cm Blood flow. When lumen diameter increased to 0.8 cm or blood flow increased to 20 cm / s, blood flow was only partially occluded. Change the tissue adhesive and lipiodol ratio of 0.5: 0.8 and 0.5: 1.0, the polymer after fracture broken into pieces. Conclusion The experimental results show that as the diameter of blood vessel increases, the velocity of blood flow increases and the ratio of concentration decreases, the effect of occlusive blood vessels of tissue adhesives decreases for clinical quantitative reference.