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目的:探讨清热解毒利咽方配合放疗对鼻咽癌的疗效及口腔黏膜的保护作用。方法:选择66例鼻咽癌患者为研究对象,按照随机的原则分为治疗组和对照组。对照组给予临床常规放疗治疗,治疗组在放疗治疗基础上给予自拟清热解毒利咽方治疗。经治疗后,观察患者临床症候体征变化,分析比较两组治疗前后急性放射性口咽黏膜反应、生活质量、行为状态以及免疫细胞变化。结果:治疗组总有效率为93.9%,对照组为84.8%,治疗组高于对照组(P<0.05);治疗组治疗后急性放射性口咽黏膜反应显著低于对照组(P<0.05);治疗后,两组KPS评分和QOL评分均呈现升高(P<0.05),且治疗组治疗后KPS评分和QOL评分均显著高于对照组(P<0.05);治疗后,治疗组CD3+、CD4+、CD4+/CD8+和NK细胞均显著性升高(P<0.05),而对照组CD3+、CD4+、CD4+/CD8+和NK细胞均显著性降低(P<0.05);组间比较中,治疗组治疗后CD3+、CD4+、CD4+/CD8+和NK细胞均显著高于对照组(P<0.05)。结论:清热解毒利咽方辅助放疗治疗鼻咽癌,能够显著提高治疗效果和患者生存质量,调节机体免疫机能,增强自身抗肿瘤能力。
Objective: To investigate the curative effect of Qingre Jiedu Liyan Recipe combined with radiotherapy on nasopharyngeal carcinoma and the protective effect of oral mucosa. Methods: Sixty-six patients with nasopharyngeal carcinoma were selected as study subjects and divided into treatment group and control group randomly. The control group was given routine radiotherapy, and the treatment group was given self-made heat-clearing, detoxifying and pharyngotherapy treatment on the basis of radiotherapy. After treatment, the signs of clinical symptoms were observed. The changes of acute radioactive oropharyngeal mucosa, quality of life, behavioral status and immune cells were compared before and after treatment. Results: The total effective rate was 93.9% in the treatment group and 84.8% in the control group, which was significantly higher in the treatment group than in the control group (P <0.05). The acute radioactive oropharyngeal mucosal response in the treatment group was significantly lower than that in the control group (P <0.05). After treatment, the KPS score and QOL score of both groups showed an increase (P <0.05), and the KPS score and QOL score of the treatment group were significantly higher than those of the control group (P <0.05). After treatment, the levels of CD3 +, CD4 + , CD4 + / CD8 + and NK cells were significantly increased (P <0.05), while the levels of CD3 +, CD4 +, CD4 + / CD8 + and NK cells in the control group were significantly decreased (P <0.05) CD3 +, CD4 +, CD4 + / CD8 + and NK cells were significantly higher than those in the control group (P <0.05). Conclusion: Qingre Jiedu Liyan Fang adjuvant radiotherapy for nasopharyngeal carcinoma, can significantly improve the treatment effect and quality of life of patients, regulate the immune function and enhance their anti-tumor ability.