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目的探讨老年男性高血压患者血清硫酸脱氢表雄酮(DHEA-S)水平与认知功能的相关性。方法选取华北理工大学附属医院的老年男性高血压患者330例。采用国际通用的简易智力状况量表(MMSE)进行认知功能评分。根据评分结果将患者分为认知功能障碍组(病例组)与认知功能正常组(对照组)。记录患者的一般临床资料,测量血压、身高、体重,收集其临床检验结果,包括空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白(LDL),采用放免法检测血清DHEA-S水平。比较以上2组一般资料及DHEA-S水平是否存在差异;分析DHEA-S与一般资料及MMSE评分的相关性。结果 (1)单因素分析结果显示:年龄、文化程度、TG、HDL-C、DHEA-S在病例组与对照组之间的差异有统计学意义(均P<0.05)。(2)多元线性回归分析显示:DHEA-S与年龄、TG、SBP呈负相关,与HDL-C呈正相关(均P<0.05)。(3)Logistic多因素回归分析显示:DHEA-S(OR:2.15;CI:1.10~4.33;%P<0.05)与老年男性高血压患者认知功能相关。结论老年男性高血压患者血清DHEA-S水平降低可能是其出现认知功能障碍的危险因素之一。
Objective To investigate the relationship between serum DHEA-S level and cognitive function in elderly hypertensive patients. Methods 330 elderly hypertensive patients in North China University Hospital were selected. Cognitive functional scores were assessed using the MMSE (Universal Simplified Mental Status Scale). The patients were divided into cognitive dysfunction group (case group) and normal cognitive function group (control group) according to the score results. The general clinical data of patients were recorded and their blood pressure, height and weight were measured. The clinical test results including fasting blood glucose (FPG), total cholesterol (TC), triglyceride (TC) and high density lipoprotein cholesterol (HDL- , Low density lipoprotein (LDL), using radioimmunoassay serum DHEA-S levels. The above two groups of general information and DHEA-S levels were compared whether there is a difference; analysis of DHEA-S and general information and MMSE score relevance. Results (1) The results of univariate analysis showed that the differences of age, education level, TG, HDL-C and DHEA-S between the case group and the control group were statistically significant (all P <0.05). (2) Multiple linear regression analysis showed that DHEA-S was negatively correlated with age, TG and SBP, and positively correlated with HDL-C (all P <0.05). (3) Logistic regression analysis showed that DHEA-S (OR: 2.15; CI: 1.10-4.33;% P <0.05) was associated with cognitive function in elderly male patients with hypertension. Conclusions The decrease of serum DHEA-S in elderly male patients with hypertension may be one of the risk factors of cognitive dysfunction.