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目的了解本地区男女患者泌尿生殖道支原体感染状况及耐药特征,为临床诊疗及合理用药提供依据。方法选取2011年1月-2015年12月门诊及住院患者,采集泌尿生殖道标本做支原体培养,并对阳性标本进行药敏试验,对阳性标本及其药敏结果进行分析。结果 2011-2015年男女患者的感染率和总感染率呈逐年递增趋势(P<0.01),女性感染者高于男性,男女患者均以Uu单纯感染为主,不同年度均以21~30岁年龄段患者为主,占合计的51.0%,药敏试验表明Uu+Mh混合感染的耐药率明显高于Uu、Mh单纯感染,Uu+Mh混合感染对克拉霉素、阿奇霉素、罗红霉素、环丙沙星的耐药率均>90.0%,Uu、Mh和Uu+Mh对美满霉素、强力霉素、交沙霉素的耐药率较低,均<10.0%。结论本地区支原体感染呈逐年上升趋势,女性感染率高于男性,年龄21~30岁患者居多,并以Uu单纯感染为主,治疗支原体感染首选美满霉素、强力霉素、交沙霉素。
Objective To understand genitourinary tract mycoplasma infection and drug resistance characteristics of male and female patients in this area and provide evidence for clinical diagnosis and treatment. Methods From January 2011 to December 2015, outpatients and inpatients were enrolled in this study. Urogenital tract specimens were collected for mycoplasma culture. Positive samples were tested for drug susceptibility. Positive samples and their susceptibility results were analyzed. Results The prevalence rate and total infection rate of male and female patients increased year by year in 2011-2015 (P <0.01), and were higher in women than in male patients. Both male and female patients were predominantly infected with Uu. The average annual prevalence was 21-30 years The majority of patients, accounting for 51.0% of the total, drug susceptibility test showed that the drug resistance rate of mixed infection of Uu + Mh was significantly higher than that of Uu, Mh simple infection, Uu + Mh mixed infection of clarithromycin, azithromycin, roxithromycin, Ciprofloxacin resistance rates were> 90.0%, Uu, Mh and Uu + Mh lower rates of minocycline, doxycycline, josamycin resistance, were <10.0%. Conclusions The prevalence of mycoplasma in the local area is increasing year by year. The infection rate of the female is higher than that of the male. The majority of patients aged 21-30 years old are mainly infected with Uu. Myzomycin, doxycycline and josamycin are the first choice for mycoplasma infection.