胶质瘤是成人最常见的脑部恶性肿瘤,由于对化疗放疗的抗性以及术后复发等原因,预后较差。在过去的10年中,激活内源性p53通路或者通过引入野生型p53恢复其功能已经用于抑制肿瘤增殖并被深入探讨。由于胶质瘤与其他实体恶性肿瘤相比有更高的p53变异发生,所以基于p53的治疗对于胶质瘤更加适合。 Glioma is the most common brain malignancy in adults. Due to resistance to chemoradiotherapy and recurrence after surgery, the prognosis is poor. In the past 10 years, activation of endogenous p53 pathways or restoration of their function by the introduction of wild-type p53 has been used to suppress tumor proliferation and is explored in depth. Since gliomas have a higher p53 mutation than other solid malignancies, p53-based therapies are more suitable for gliomas.