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恶性疟对抗疟药物抗性的逐渐提高已成为热带地区的主要威胁。对氯喹的抗性已非常普遍,对甲氟喹的抗性也快速上升。在泰-缅边界地区,甲氟喹对恶性疟的有效治疗剂量已从15mg/kg上升到25mg/kg,但治愈率持续下降。近来人们尝试用甲氟喹和青蒿酯5天联合疗法以提高治愈率而不增加毒性作用。但因病人不能配合服完3天以上疗程的药物,所以此联合用药计划不能很好地实施。本文作者用低剂量的甲氟喹15mg/kg与青蒿酯10mg/kg伍用一天,评价其有效性和毒性,以便替代高剂量的甲氟喹治疗。
The gradual increase in resistance of antimalarial drugs to P. falciparum has become a major threat in the tropics. Chloroquine resistance has been very common, resistance to mefloquine is also rapidly rising. Effective doses of mefloquine to falciparum malaria have risen from 15 mg / kg to 25 mg / kg in the Thai-Burmese border region, but the cure rate has been declining. Recently people tried mefloquine and artemisinin combination therapy for 5 days to improve the cure rate without increasing the toxic effect. However, because the patient can not cope with the medication over 3 days, the combination plan can not be implemented well. The authors used a low dose of mefloquine 15mg / kg and artesunate 10mg / kg one day to evaluate its effectiveness and toxicity in order to replace the high-dose mefloquine treatment.