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目的探讨川芎葡萄糖注射液联合奥扎格雷纳氯化钠注射液治疗急性脑血栓的临床效果。方法选取2013年6月—2014年6月迁安首钢矿山医院收治的急性脑血栓患者100例,根据不同的治疗方式将患者分为观察组与对照组,每组50例。对照组患者给予奥扎格雷纳氯化钠注射液静脉滴注,观察组患者在对照组基础上联合川芎葡萄糖注射液静脉滴注,比较两组患者临床效果、日常生活能力量表(Bathel)评分、神经功能缺损评分及不良反应发生情况。结果观察组患者总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后15、30、60d观察组患者Bathel评分高于对照组,差异有统计学意义(P<0.05)。治疗前两组患者神经功能缺损评分比较,差异无统计学意义(P>0.05);治疗后15、30、60d观察组患者神经功能缺损评分低于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论川芎葡萄糖注射液联合奥扎格雷纳氯化钠注射液治疗急性脑血栓的临床效果确切,可有效改善患者神经功能缺损程度,提高生活自理能力,且不增加不良反应。
Objective To investigate the clinical effect of ligusticum chuanxiong glucose injection and ozagrel sodium chloride injection in the treatment of acute cerebral thrombosis. Methods From June 2013 to June 2014, 100 patients with acute cerebral thrombosis admitted from Shougang Mining Hospital in Qian’an were selected. According to the different treatment methods, the patients were divided into observation group and control group with 50 cases in each group. Patients in the control group were given intravenous infusion of sodium ozagrellate sodium chloride injection. Patients in the observation group received intravenous infusion of Ligusticum chuanxiong and glucose injection on the basis of the control group. The clinical effects, Bathel score , Neurological deficit score and incidence of adverse reactions. Results The total effective rate of observation group was higher than that of control group, the difference was statistically significant (P <0.05). The Bathel score of the observation group was higher than that of the control group on the 15th, 30th, 60th day after treatment (P <0.05). There was no significant difference in the score of neurological deficit between the two groups before treatment (P> 0.05). The score of neurological deficit in observation group was lower than that of control group on the 15th, 30th and 60th day after treatment (P <0.05) ). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion Chuanxiong glucose injection combined with sodium ozagrella sodium chloride injection in the treatment of acute cerebral thrombosis clinical effect is exact, can effectively improve the degree of neurological deficits in patients with self-care ability, and does not increase adverse reactions.