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目的探讨封闭抗体(BA)在早初孕和不良妊娠妇女人群中的分布情况及其相关性研究。方法收集该院妇科460例正常早初孕和不良妊娠病例,分为健康早初孕组212例(对照组)和不良妊娠组248例[包括不明原因复发性自然流产(UR-SA)、继发性不孕、偶发性自然流产3组]。采用ELISA法检测各病例组血清中的BA。结果各组BA阳性率分别为对照组50.9%(108/212),URSA组26.8%(22/82),继发不孕组42.9%(48/112),偶发性自然流产组70.4%(38/54)。各组BA阳性率及总体之间比较差异有统计学意义(P<0.05);对照组与URSA组比较差异有统计学意义(P<0.05),与偶发性自然流产组和继发性不孕组比较差异无统计学意义(P>0.05)。结论 BA缺失和URSA发生有关,与继发性不孕和偶发性自然流产无明显相关。
Objective To investigate the distribution of the blocking antibody (BA) in early pregnancy and adverse pregnancy women population and its correlation study. METHODS: A total of 460 cases of normal early pregnancy and unhealthy pregnancy were collected from gynecology department of gynecology hospital. The patients were divided into two groups: healthy early pregnancy group (212 cases) and negative pregnancy group (248 cases), including unexplained recurrent spontaneous abortion (UR-SA) Infertility, sporadic spontaneous abortion 3 groups]. Serum BA was detected by ELISA in each case. Results The positive rate of BA in each group was 50.9% (108/212) in the control group, 26.8% (22/82) in the URSA group, 42.9% (48/112) in the secondary infertility group and 70.4% (38.4%) in the spontaneous abortion group / 54). The positive rate of BA in each group and the overall difference was statistically significant (P <0.05); the control group and the URSA group, the difference was statistically significant (P <0.05), and spontaneous abortion group and secondary infertility There was no significant difference between the two groups (P> 0.05). Conclusion The deletion of BA is related to the occurrence of URSA and has no significant correlation with secondary infertility and sporadic spontaneous abortion.