论文部分内容阅读
含生药量分别为２５％和１２．５％的冻疮搽剂降低小鼠炎症性耳肿胀分别为８．７±３．３和９．９±４．２μｇ，对照组为１３．８±２．８ｍｇ（Ｐ＜０．０５或０．０１）；提高豚鼠对组胺的致痒阈分别为２７０．５±２９．４和９４．０±４１．６μｇ，对照组为３０．０±２９．４μｇ（Ｐ＜０．０１）；拮抗炎性刺激所致毛细血管通透性吸光度分别为０．１１±０．０３和０．１３±０．０３，对照组为０．２２±０．０３（Ｐ＜０．０１）；消除大鼠蛋清所致脚趾肿胀，６ｈ末分别为０．１１±０．０８和０．１３±０．１３ｃｍ￣３，与对照组０．３５±０．１２ｃｍ￣３均有显著差异（Ｐ＜０．０１）．结果表明冻疮搽剂具有广泛的药理作用，是治疗冻疮的有效制剂。
Frostbite liniment containing 25% and 12.5% of the crude drug, respectively, reduced the inflammatory ear swelling in mice by 8.7 ± 3.3 and 9.9 ± 4.2μg, respectively, compared with 13.8 ± 2 in the control group. 8mg (P <0.05 or 0.01). The itch-raising threshold for histamine in guinea pigs were 270.5 ± 29.4 and 94.0 ± 41.6μg, respectively. The control group was 30.0 ± 29.4μg (P <0.01). Capillary permeability absorbance induced by antagonistic inflammatory stimuli was 0.11 ± 0.03 and 0.13 ± 0.03, respectively, and the control group was 0.22 ± 0.03 (P <0.01); Elimination of rat egg white induced toe swelling, respectively, at the end of 6h were 0.11 ± 0.08 and 0.13 ± 0.13cm ~ 3, compared with the control group 0.35 ± 0.12cm ~ 3 There was a significant difference (P <0.01). The results show that frostbite liniment has a wide range of pharmacological effects, is an effective preparation for the treatment of frostbite.