人类白细胞抗原(human leucocyte antigen,HLA)复合体是人体中基因多态性最高的基因复合体,其多态性与疾病遗传易感性显著相关。人类白细胞抗原-F(human leucocyte antigen-F,HLA-F)属于非经典HLA I类分子中的一员,与HLA-E、-G在结构上十分相似,具有有限的多态性。近年来多数学者聚焦于HLA-F基因转录及分子表达调控、HLA-F表达与临床相关性及HLA-F抗体研制,且取得了重要成果。就HLA-F的研究进展作一综述。 The human leucocyte antigen (HLA) complex is the gene complex with the highest genetic polymorphism in the human body, and its polymorphism is significantly associated with the genetic predisposition of the disease. Human leukocyte antigen-F (HLA-F) belongs to a class of non-classical HLA class I molecules and has very limited polymorphism with HLA-E and -G. In recent years, most scholars have focused on the regulation of HLA-F gene transcription and molecular expression, HLA-F expression and clinical relevance, and the development of HLA-F antibodies, and achieved important results. The research progress of HLA-F is reviewed.