为探索长期低剂量接触对苯二甲酸( TPA) 、乙二醇( EG) 、联苯联苯醚( DOW) 对工人健康的影响,采用职业流行病学的方法,对某化纤公司1230 名TPA、EG、DOW 作业工人和177 名对照工人进行调查。结果表明,接触组血清ALT、GGT、ALP 活性和尿β2MG 含量明显高于对照组(P< 0-05 或P< 0-01) ;接触组尿蛋白红细胞阳性检出率分另为3-25 % 、6-42 % ,与对照组相比有显著差异(P< 0-05 或P< 0-01) 。提示长期接触低浓度TPA、EG、DOW 可引起工人的肝肾功能改变;TPA、EG、DOW 对作业工人的职业损伤存在联合作用的可能。综合效应评价结果表明,该化纤公司职业危害呈逐年上升趋势 In order to explore the impact of long-term low-dose exposure to terephthalic acid (TPA), ethylene glycol (EG) and diphenyl-diphenyl ether (DOW) on workers’ health, a professional epidemiological method was used to investigate the effects of low- TPA, EG, DOW workers and 177 control workers. The results showed that the serum ALT, GGT, ALP activity and urinary β2MG content in the exposed group were significantly higher than those in the control group (P <0-05 or P <0-01); the positive rate of urinary protein erythrocytes in the contact group was 3 -25% and 6-42% respectively, which were significantly different from the control group (P <0-05 or P <0-01). It suggested that long-term exposure to low concentrations of TPA, EG, DOW can cause liver and kidney function changes in workers; TPA, EG, DOW on occupational occupational injury workers may have a joint role. The comprehensive effect evaluation results show that the chemical company occupational hazards showed a rising trend year by year