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目的 观察注射用鼠神经生长因子对老年痴呆的疗效及血清细胞因子的影响.方法 90例老年痴呆患者随机分为试验组45例和对照组45例.对照组给予常规治疗,试验组在常规治疗的基础上静脉滴注注射用鼠神经生长因子20 μg,每天1次,连续治疗6周.分别于治疗前、治疗后6,12周评定2组患者认知功能、痴呆程度、日常生活自理能力,并用酶联免疫吸附试验检测血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平.结果 治疗12周后,2组简易智力状况检查法(MMSE)、日常活动能力(ADL)、临床痴呆评定量表(CDR)差异有统计学意义(P＜0.05).试验组治疗后6,12周的血清IL-1β分别为(20.88±5.83),(18.35±3.96)ng· L-1,IL-6为(24.33±8.56),(18.85±5.83)ng· L-1,CRP分别为(6.43±1.65),(5.27±0.63) ng·L-1,TNF-α分别为(40.52±8.33),(36.34±5.92)ng·L-1;对照组IL-1β分别为(21.12±6.12),(20.76±4.83)ng· L-1,IL-6为(24.84±9.13),(21.64±6.68) ng·L-1,CRP为(6.73±1.73),(6.17±0.95)ng· L-1,TNF-α为(40.85±9.15),(39.46±6.44) ng·L-1.治疗12周后,2组IL-1β、IL-6、CRP、TNF-α差异有统计学意义(P＜0.05).对照组出现轻度头疼1例,药物不良反应发生率为0.02％(1/45例),试验组未发生药物不良反应.结论 注射用鼠神经生长因子对老年痴呆患者临床疗效显著,可改善患者生活能力,舒缓痴呆症状,降低机体血清细胞因子水平.“,”Objective To evaluate the clinical effect and serum cytokines levels of mouse nerve growth factor during the treatment of senile dementia.Methods A total of 90 senile dementia patients were randomly divided into treatment group and control group,each group 45 cases.Control group was given conventional treatment.Treatment group was intravenous drip mouse nerve growth factor 20 μg,qd on the basis of control group.All patients were treated for 6 weeks.The cognitive function,dementia degree,daily life ability before treatment and 6,12 weeks after treatment in two groups were observed.The levels of serum interleukin-1β (IL-1β),interleukin-6 (IL-6),C-reactive protein(CRP),tumor necrosis factor-α (TNF-α) in two group were observed.Results The mental state examination(MMSE),activity of daily life (ADL),clinical dementia rating (CDR) in two group after 12 weeks treatment had significant difference (P ＜ 0.05).The IL-1 β in treatment group after 6,12 weeks treatment were (20.88 ± 5.83),(18.35 ±3.96) ng · L-1,and were (21.12 ±6.12),(20.76 ±4.83) ng· L-1 in control group.The IL-6 in treatment group after 6,12 weeks treatment were (24.33 ± 8.56),(18.85 ±5.83) ng · L-1,and were (24.84 ±9.13),(21.64 ± 6.68) ng · L-1 in control group.The CRP in treatment group after 6,12 weeks treatment were (6.43 ± 1.65),(5.27 ± 0.63)ng · L-1,and were (6.73 ± 1.73),(6.17 ± 0.95) ng · L-1 in control group.The TNF-α in treatment group after 6,12 weeks treatment were (40.52 ±8.33),(36.34 ±5.92) ng · L-1,and were (40.85 ±9.15),(39.46 ±6.44) ng · L-1 in control group.The IL-1β,IL-6,CRP,TNF-α in two group after 12 weeks treatment had significant difference (P ＜0.05).There was 1 case of mild headache in control group,the incidence of adverse drug reactions was 0.02％ (1/45 cases).There was no adverse drug reaction occurred in treatment group.Conclusion The clinical effect of nerve growth factor in the treatment of senile dementia is significant,and can improve the living ability,relieve the symptoms of dementia,reduce the level of serum cytokines.