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目的探讨阴茎癌及其癌旁组织中癌基因ｒａｓ产物Ｐ２１蛋白表达的临床意义。方法用免疫组化ＡＢＣ法检测３２例阴茎癌、３２例癌旁组织和１６例正常阴茎组织的癌基因ｒａｓ产物Ｐ２１蛋白。结果２８例癌组织，８例癌旁组织中有Ｐ２１蛋白表达，而１６例正常阴茎组织中Ｐ２１阴性。Ｐ２１蛋白和病理分级、临床分期呈正相关表达，即随分级和分期的上升阳性增强，并且癌旁组织Ｐ２１蛋白表达阳性者显示早期复发和转移的不良预后。结论Ｐ２１蛋白可作为阴茎癌的生物学指标。
Objective To investigate the clinical significance of P21 protein expression in oncogene ras in penile cancer and its adjacent tissues. Methods P21 protein was detected by immunohistochemical ABC method in 32 cases of penile cancer, 32 cases of adjacent tissues and 16 cases of normal penile tissue. Results P21 protein expression was found in 28 cases of cancer tissues and 8 cases of paracancerous tissues, while P21 was negative in 16 cases of normal penile tissues. P21 protein and pathological grade, clinical stage was positively correlated, that is, with the grade and staging increased positive, and P21 protein expression in paracancerous tissues showed poor prognosis of early recurrence and metastasis. Conclusion P21 protein can be used as a biological indicator of penile cancer.