论文部分内容阅读
老龄化导致人体骨强度降低,骨折几率增加;肿瘤,创伤和骨质疏松症等疾病也会引起骨缺陷。因此,骨替代材料的需求日益增加,寻找一种理想的骨替代材料显得尤为重要。天然骨中最重要的无机和有机成分是羟基磷灰石和胶原蛋白,两者都具有良好的生物学性能,但是单独使用时,羟基磷灰石的降解性较差,而胶原蛋白的硬度不够高,难以满足组织工程对生物材料性能的要求。在本研究中,以重组胶原蛋白,氯化钙和磷酸为原料,在室温环境下,以重组胶原蛋白为模板,通过改变反应时间和磷酸根的浓度,制备性能良好的重组胶原蛋白-羟基磷灰石复合纳米材料。我们通过XRD、FTIR、SEM、TGA等技术对复合材料的晶相、化学键结构、微观形貌和组份进行了表征,发现可以通过控制反应时间和磷酸根浓度调控该复合纳米材料的微观形貌。
Aging leads to lower body strength and increased risk of bone fracture; diseases such as cancer, trauma and osteoporosis can also cause bone defects. Therefore, the increasing demand for bone substitute materials, looking for an ideal bone substitute material is particularly important. The most important inorganic and organic components of natural bones are hydroxyapatite and collagen, both of which have good biological properties, but hydroxyapatite is less degradable when used alone, while the hardness of collagen is not sufficient High, difficult to meet the requirements of tissue engineering on the performance of biological materials. In this study, the recombinant collagen, calcium phosphate and phosphoric acid as raw materials at room temperature, the recombinant collagen as a template, by changing the reaction time and phosphate concentration, the preparation of good performance recombinant collagen - hydroxy phosphorus Graystone composite nanomaterials. The XRD, FTIR, SEM, TGA and other techniques were used to characterize the crystal phase, chemical bond structure, micro-morphology and composition of the composites. It was found that the microstructure of the composite nanomaterials can be controlled by controlling the reaction time and the concentration of phosphate .