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对１２例全大型重症肌无力（ＭＧ）患者周围血Ｂ细胞增殖及分化能力进行了研究，并观察重组白细胞介素２（ｒＩＬ－２）及Ｔ细胞亚群对其直接与间接影响。结果表明：①ＭＧ患者周围血Ｂ细胞的增殖能力高于健康人，ｒＩＬ－２及Ｔ细胞亚群可促进Ｂ细胞的增殖；②去ＣＤ８＋细胞后ＡＣｈＲ－ａｂ的产生无明显增加；③去ＣＤ４＋细胞组加入ｒＩＬ－２后ＡＣｈＲ－ａｂ产生减少。提示ｒＩＬ－２对ＭＧ患者有潜在的治疗价值。
The proliferation and differentiation of B cells in peripheral blood of 12 patients with complete myasthenia gravis (MG) were studied, and the direct and indirect effects of recombinant interleukin 2 (IL-2) and T cell subsets were observed. The results showed that: (1) The proliferative capacity of B cells in peripheral blood of patients with MG was higher than that of healthy people, rIL-2 and T lymphocyte subsets promoted the proliferation of B cells; (2) No obvious increase of AChR-ab in CD8 + cells; AChR-ab production decreased after addition of rIL-2. Suggesting that rIL-2 has potential therapeutic value for MG patients.