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目的 探讨窒息新生儿血浆胆红素水平的变化。方法 对 39例窒息新生儿 (重度组 2 0例 ,轻度组19例 )及同期出生的正常足月新生儿 2 2例 (对照组 ) ,分别于出生后 4～ 5天胆红素高峰期进行足跟毛细血管血胆红素水平测定。结果 重度组低于轻度组 ,P <0 0 1;轻度组低于对照组 ,P <0 0 1,各组间均存在显著性差异。结论 新生儿窒息后胆红素水平的降低与如下因素有关①胆红素作为抗氧化剂被窒息后再灌注损伤产生的大量氧自由基所消耗 ,②宫内窒息后胎粪排出 ,肠肝循环减少 ,③窒息时胆囊扩张、胆汁潴留
Objective To investigate the changes of plasma bilirubin levels in neonates with asphyxia. Methods Thirty-nine neonates with asphyxia (20 cases in severe group and 19 cases in mild group) and 22 normal term neonates (control group) were enrolled in this study. They were treated with bilirubin 4 to 5 days after birth Heel capillary blood bilirubin levels were measured. Results The severe group was lower than the mild group, P <0.01; the mild group was lower than the control group, P <0.01, there were significant differences among the groups. Conclusions The decrease of bilirubin level in neonates with asphyxia is related to the following factors: ① bilirubin is consumed as a large amount of oxygen free radicals produced by perfused injury after asphyxiation, ② the discharge of meconium after asphyxia and the decrease of enterohepatic circulation , ③ gallbladder dilatation asphyxia, bile retention