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目的:研究阿托伐他汀片与血栓通注射液联合治疗对脑梗死患者血脂及血液流变学的影响。方法:选取我院从2012年2月到2014年2月收治的急性脑梗死患者100例,分成两组,每组各50例。对照组静脉滴注血栓通注射液,试验组静脉滴注血栓通注射液加口服阿托伐他汀片治疗。14天后观察两个组的治疗效果,并且进行血脂(TC、TG、LDL-C、HDL-C)、血液流变学(血浆粘度、全血高切粘度、全血低切粘度、全血还原黏度、纤维蛋白原、细胞刚性指数)等指标的检测,以及疗效及不良反应情况。结果:治疗后试验组TC、TG、LDL-C低于对照组,HDL-C高于对照组,且具有统计学意义(P<0.05)。治疗后,试验组血浆粘度、全血高切粘度、全血低切粘度、全血还原黏度、纤维蛋白原、细胞刚性指数均低于对照组,且具有统计学意义(P<0.05)。试验组总有效率为88.0%(44/50),高于对照组的66.0%(33/50)(P<0.05)。试验组发生不良反应发生率与对照组比较无统计学意义(P>0.05)。结论:阿托伐他汀片联合血栓通注射液对于脑梗死患者的血脂和血液流变学的影响疗效显著,且具有明显的降脂效果。
Objective: To study the effects of combination of atorvastatin tablets and Xueshuantong injection on blood lipids and hemorrheology in patients with cerebral infarction. Methods: A total of 100 acute cerebral infarction patients admitted from February 2012 to February 2014 in our hospital were divided into two groups, 50 cases in each group. Control group intravenous injection of Xueshuantong injection, test group intravenous injection of Xueshuantong injection plus oral atorvastatin tablets treatment. After 14 days, the therapeutic effects of the two groups were observed and the blood lipids (TC, TG, LDL-C and HDL-C), hemorheology (plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, Viscosity, fibrinogen, cell rigidity index) and other indicators of detection, and efficacy and adverse reactions. Results: The levels of TC, TG and LDL-C in the experimental group after treatment were lower than those in the control group, and the HDL-C levels were higher than those in the control group (P <0.05). After treatment, the plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, whole blood reduced viscosity, fibrinogen and cell rigidity index were all lower than those of the control group (P <0.05). The total effective rate in the experimental group was 88.0% (44/50), which was higher than that in the control group (66.0%, 33/50) (P <0.05). The incidence of adverse reactions in the experimental group compared with the control group was not statistically significant (P> 0.05). Conclusion: Atorvastatin tablets combined with Xueshuantong injection have significant effects on the blood lipids and hemorheology in patients with cerebral infarction, and have a significant lipid-lowering effect.