氯氮平为抗精神病药,英国药品安全委员会已收到8例惊厥反应报道,其中只有1例以前有过癫痫发作史。这些病人每日服用剂量从25mg 到800mg 不等,而且从开始治疗到惊厥发作的时间间隔变动在5天到6个月之间。委员会认为在易感病人的血浆中较高浓度的药量会引起惊厥,因此,建议在治疗 Clozapine is an antipsychotics, the British Drug Safety Commission has been reported in 8 cases of seizures, of which only 1 had a history of seizures. These patients dosed daily doses ranging from 25 mg to 800 mg, and the time interval between initiation of treatment and seizures varied between 5 days and 6 months. The committee believes that higher concentrations of medications in the plasma of susceptible patients can cause convulsions and it is therefore advisable to treat