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研究铅的神经行为效应及其对尿中单胺类递质代谢物的影响。方法：采用ＷＨＯ ＮＣＴＢ测试铅冶炼工和蓄电池厂铅接触工人的神经行为功能，并收集晨尿分析尿中香草扁桃酸（ＶＭＡ）和５-羟吲哚乙酸 （ ５－ＨＩＡＡ）含量。结果：铅接触组血铅（ Ｐｂ－Ｂ）在 １９、８μｇ／ｄｌ水平时，与对照组相比，可引起机体某些行为功能变化、尿中单胺类递质去甲肾上腺素代谢物ＶＭＡ显著上升。Ｐｂ－Ｂ水平与反映眼－手快速协调能力的手提转捷度测试（ＳＡＮ）得分呈负相关，而与尿中ＶＭＡ呈正相关。结论：神经行为功能是神经毒性敏感的指标，单胺类递质的变化可能为铅致神经行为功能改变的神经生化机制之一。
To study the neurobehavioral effects of lead and its effect on monoamine metabolites in urine. Methods: The neurobehavioral function of lead contact workers in lead smelters and battery factories was tested by WHO NCTB. The contents of VMA and 5-HIAA in urine were collected by morning urine analysis. Results: Compared with the control group, lead-exposed group had higher levels of lead (Pb-B) at 19 and 8μg / dl, which could cause certain behavioral changes in the body. The urinary monoamine neurotransmitter norepinephrine metabolites VMA Significantly increased. The level of Pb-B was negatively correlated with the hand-wheeling test (SAN) score, which reflects the eye-hand coordination ability quickly, but positively correlated with the VMA in the urine. CONCLUSION: Neurobehavioral function is a sensitive indicator of neurotoxicity. The changes of monoamine neurotransmitters may be one of the neurobiochemical mechanisms that lead to behavioral changes of lead-induced neurobehavior.