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目的应用Meta分析方法探讨术后辅助化疗对Ⅰ、Ⅱ非小细胞肺癌预后的影响。方法在MEDLINE、Highwire及中国学术期刊全文数据库(CNKI)、维普学术期刊全文数据库检索有关Ⅰ、Ⅱ期非小细胞肺癌根治术后辅助化疗的临床对照研究,分别对入选的研究进行文献评价,最后提取资料进行Meta分析。结果从1997至2007年共有16个研究入选,试验组共2048例,对照组2 046例,分析结果显示手术后行辅助化疗组与单纯手术组相比死亡风险优势比OR=0.88(95%CI0.76~1.01),P值等于0.06,差异无统计学意义。结论Ⅰ、Ⅱ期NSCLC根治术后辅助化疗能否提高患者生存率仍不明确,需要进一步研究。
Objective To evaluate the effect of postoperative adjuvant chemotherapy on the prognosis of patients with non-small cell lung cancer Ⅰ and Ⅱ by Meta-analysis. Methods The clinical data of MEDLINE, Highwire, CNKI and VIP database were searched for the clinical control study of adjuvant chemotherapy after radical resection of stage I and II non-small cell lung cancer. Extracted data for meta-analysis. Results From 1997 to 2007, a total of 16 studies were enrolled. There were 2048 cases in the trial group and 2 046 cases in the control group. The analysis showed that the odds ratio of mortality risk after surgery with adjuvant chemotherapy was OR = 0.88 (95% CI0 .76 ~ 1.01), P value is equal to 0.06, the difference was not statistically significant. Conclusions It is still not clear whether adjuvant chemotherapy with stage Ⅰ and Ⅱ NSCLC can improve the survival rate of patients, which needs further study.