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目的探讨血清1,5-脱水葡萄糖醇(1,5-AG)与糖尿病肾病(DN)的关系。方法选取80例2型糖尿病(T2DM)并发DN患者为DN组,138例T2DM非DN患者为非DN组,应用葡萄糖-吡喃糖氧化酶酶偶联两点法检测两组患者的血清1,5-AG水平,同时测定糖化血红蛋白(HbAlc)、尿素(Urea)、血尿酸(UA)及黄素单核苷酸(FMN)等指标,并分析其与DN的关系。结果 DN组血清1,5-AG水平明显低于非DN组,差异有统计学意义(P<0.05),DN组年龄、T2DM病程、Cr、UA及FMN与非DN组比较差异有统计学意义(P<0.05)。而两组高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白(LDL-C)、甘油三酯(TG)、胆固醇(TC)以及HbAlc各指标比较差异无统计学意义(P>0.05)。结论 T2DM并发DN患者血清1,5-AG水平明显降低,检测T2DM患者血清1,5-AG水平有利于评估DN的发病风险,对于减少T2DM患者DN的发病率具有一定的意义。
Objective To investigate the relationship between serum 1,5-anhydroglucitol (1,5-AG) and diabetic nephropathy (DN). Methods Totally 80 DN patients with type 2 diabetes mellitus (T2DM) were selected as DN group and 138 non-DN patients with T2DM as non-DN group. Serum levels of serum 1 were measured by glucose-pyranose oxidase and enzyme- 5-AG levels were measured. The indexes of HbAlc, Urea, UA and FMN were measured at the same time, and their relationship with DN was analyzed. Results The serum level of 1,5-AG in DN group was significantly lower than that in non-DN group (P <0.05). There was significant difference in age, T2DM course, Cr, UA, FMN and DN between DN group and DN group (P <0.05). There was no significant difference between the two groups in HDL-C, LDL-C, triglyceride (TG), cholesterol (TC) and HbAlc (P> 0.05) . Conclusions Serum 1,5-AG levels in T2DM patients with DN are significantly lower. Detecting serum 1,5-AG levels in patients with T2DM is helpful to assess the risk of DN and is of significance in reducing the incidence of DN in T2DM patients.