血管形成素(Angiopoietin,Ang)为血管内皮细胞(endothelial cells,ECs)特异性受体酪氨酸激酶Tie-2的配体,是一类新发现的血管生成因子,它与血管内皮生长因子(vascularendothelial growth factor,VEGF)共同作用,协同调节血管的发生、形成过程[1]。Ang-1是Tie-2的主要生理配体,其功能涉及:募集与支持血管内皮周围细胞、诱导毛细血管发芽、ECs趋化反应和ECs网络形成[2]、与抗ECs凋亡有关[3,4]。Ang-1或Tie-2基因敲除的小鼠心脏、脑及卵黄囊血管系统的 Angiopoietin (Ang) is a ligand of Tie-2, a receptor tyrosine kinase specific receptor of vascular endothelial cells (ECs), is a newly discovered angiogenic factor that interacts with vascular endothelial growth factor vascularendothelial growth factor, VEGF) synergistic effect, synergistically regulate the occurrence of blood vessels, the formation process [1]. Ang-1 is a major physiological ligand for Tie-2 and its function involves recruiting and supporting cells surrounding the vascular endothelium, inducing capillary sprouting, ECs chemotactic response and ECs network formation [2], which is associated with anti-ECs apoptosis [3 , 4]. Ang-1 or Tie-2 knockout mice heart, brain and yolk sac vasculature