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目的观察血液灌流(HP)对慢性肾衰维持性血液透析(MHD)患者血清瘦素(Leptin)的影响。方法 56例患者随机分为常规血液净化组(HD+HDF)、观察组(HD+HDF+HP),另选健康体检者20例为正常对照组,观察组在常规血液净化治疗基础上每2周加做1次HP,测定HP治疗前后及对照组血清Leptin水平。结果 MHD患者观察组和常规治疗组比较HP治疗前血清Leptin水平差异无统计学意义,但均明显高于对照组;观察组经HP治疗2、4个月后均显著低于常规治疗组。观察组治疗2、4个月后均比治疗前明显下降,治疗4个月后和治疗2个月后相比,下降差异无统计学意义。结论 HP能有效清除MHD患者血液中的Leptin,对改善患者食欲和营养状态可能有益。
Objective To observe the effect of hemoperfusion (HP) on serum leptin in chronic renal failure patients with hemodialysis (MHD). Methods 56 patients were randomly divided into routine blood purification group (HD + HDF), observation group (HD + HDF + HP), another 20 healthy subjects were normal control group, the observation group on the basis of routine blood purification treatment every 2 Week plus 1 HP, measured before and after HP treatment and control serum Leptin levels. Results There was no significant difference in serum Leptin levels between the observation group and the conventional treatment group before and after treatment with HP, but both were significantly higher than those in the control group. The levels of Leptin in the observation group and the conventional treatment group were significantly lower than those in the conventional treatment group after 2,4 and 4 months of HP treatment. The observation group after 2 and 4 months of treatment were significantly lower than before treatment, 4 months after treatment and after 2 months of treatment, the difference was not statistically significant. Conclusion HP can effectively remove Leptin in the blood of patients with MHD, which may be beneficial to improve appetite and nutritional status of patients.