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目的系统评价保留幽门胃部分切除术(PPG)治疗早期胃癌的临床效果及生活质量。方法计算机检索1995年1月至2010年12月PubMed、Wiley Online Library、中国生物医学数据库(CBM)、CNKI、VIP及万方数据库关于PPG和传统远端胃切除术(CDG)治疗早期胃癌的随机对照试验。RevMan5.0进行Meta分析。结果纳入2个随机对照试验和11个临床对照试验,共1011例病人。PPG和CDG相比,术后能减少倾倒综合征、残胃炎的发生,病人营养状况和体重恢复较好;但总并发症、胆结石、反流性食管炎无显著差别。结论现有研究表明,早期胃癌行PPG后生活质量较好。由于纳入研究方法学质量低、数量少,期待更多高质量试验提供高质量证据。
Objective To systematically evaluate the clinical effect and quality of life of reserving pyloric partial gastrectomy (PPG) for early gastric cancer. Methods We searched the PubMed, Wiley Online Library, China Biomedical Database (CBM), CNKI, VIP and Wanfang database from January 1995 to December 2010 for the randomized treatment of early gastric cancer with PPG and conventional distal gastrectomy (CDG) Control test. RevMan5.0 Meta-analysis. Results A total of 1011 patients were enrolled in two randomized controlled trials and 11 clinical control trials. Compared with CDG, PPG could reduce the occurrence of dumping syndrome and residual gastritis after operation, and patients’ nutritional status and body weight recovery were better. However, there was no significant difference in total complication, gallstone and reflux esophagitis. Conclusion The existing studies show that the quality of life of early gastric cancer after PPG is better. Due to the low quality and small number of included research methodology, more high quality trials are expected to provide high quality evidence.